Research

There are numerous research project ongoing globally. Below is not an exhaustive list and I’ll keep updating as time allows. Keep checking back for new info on the site frequently.

I. The Celiac Disease Center at Columbia University Medical Center: Has cutting edge research and 15 separate ongoing projects currently under way.

From the website: “100% of our research is focused on celiac disease. Our research reflects the nature of celiac disease as a multisystem disease. Our targets include many of humanity’s most feared illnesses, including cardiovascular disease, diabetes, cancer, thyroid disease, osteoporosis, infertility, neurological disorders, ADD, ADHD, Autism and depression as it relates to celiac disease.

Our research portfolio includes fifteen ongoing research studies in various stages of development along with an immunology research laboratory to further our understanding of the various components of the immune system involved in causing celiac disease. Our medical publications, in peer reviewed journals, attest to the value of the research. We regard the laboratory research that we are funding to be the mainstay of seeking an understanding of the immunology of celiac disease. It is through this research that there will be development of drug therapies that will be used as an adjunct to the gluten-free diet.”

Following is a list of research being conducted at the Celiac Disease Center at Columbia:

1. Clinical studies into the modes of presentation, changing patterns of presentation of celiac disease, the influence of HLA type and gender on presentation and clinical manifestations.

2. Epidemiologic study into the effects of breast feeding on the manifestations of pediatric celiac disease.

3. Quality of life study comparing patients in the United States and Europe.

4. Study of the role of video capsule endoscopy in celiac disease.

5. Risk of malignancy in celiac disease.

6. Cost effectiveness of the diagnosis of celiac disease.

7. Epidemiology of cardiovascular risk factors in celiac disease.

8. Epidemiology of disease associations including autoimmune diseases, chronic liver and heart disease.

9. Immunological mechanisms of disease.

10. Genetics of celiac disease.

11. Refractory sprue, mechanisms of disease and potential therapies.

Contact information:

Celiac Disease Center at Columbia University Harkness Pavilion 180 Fort Washington Avenue Suite 934 New York, NY 10032 Tel (212) 342-4529 Fax (212) 342-0447 Email: celiac@columbia.edu

www.celiacdiseasecenter.org

II. The University of Chicago Celiac Disease Center: Interesting and exciting clinical trials, interesting information on the website and frequent updates on celiac research news.

From the website: ” Adults with Positive Screening Blood Tests for Celiac Disease Needed for a Research Study!

The University of Chicago Celiac Disease Center is beginning a study to develop a new survey of symptoms of celiac disease. Learn more.

Study for Patients with Possible Celiac Disease

The University of Chicago Celiac Disease Center is conducting a study to evaluate the performance of a new test for the antibodies associated with celiac disease. Learn more.

Adults with Established Celiac Disease Needed for a Research Study!

The University of Chicago Celiac Disease Center is beginning a study to develop a new survey of symptoms of celiac disease. We are looking for people with celiac disease to test the new survey while eating a food with or without a small amount of gluten. Learn more.

Study for Individuals with Refractory Celiac Disease or Refractory Sprue

Do you have celiac disease but continue to have symptoms despite a strict gluten-free diet? Have you been diagnosed with refractory celiac disease or refractory sprue? Dr. Bana Jabri, in collaboration with Drs. Kupfer and Semrad, of The University of Chicago Celiac Disease Center is launching a study to better understand and identify potential therapies for individuals diagnosed with refractory celiac disease. Learn more.

To learn more about clinical trials at The University of Chicago Celiac Disease Center, please contact our clinical research coordinator, NurAlima Grandison, at ngrandison@uchicago.edu or (773) 702-3572. Don’t forget to sign up for the Center’s newsletter when you visit the site!

III. The University of Maryland Center for Celiac Research: Impressive list of research projects, targeting a number of areas important to understanding and treating celiac disease and gluten sensitivity.

From the website: “The University of Maryland Center for Celiac Research is dedicated to improving the quality of life for patients with celiac disease, while learning the cause of the disease and finding a cure. Located in downtown Baltimore, the Center for Celiac Research provides comprehensive clinical care and long-term support for adults and children who suffer from celiac disease. Celiac Disease, a genetically based-autoimmune disease, affects 1 out of every 133 people in the United States. “

 

Critical Research Areas

CFCR Discovers the Difference Between CD & Gluten Sensitivity (GS) – Our research provides the first evidence of a differ­ent mechanism leading to GS. The study also demonstrates that GS and CD are part of a spectrum of gluten-related disorders.

  • Gluten Spectrum Disorders Identified – Dr. Fasano chaired a committee to define the difference between a wheat allergy, gluten sensitivity and CD.
  • Update on Zonulin – Dr. Fasano’s article, “Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer,”presents a detailed account of the intriguing role that zonulin plays in the develop­ment of a host of diseases.
  • Innate Immune Study and Chemotaxis Study – The CFCR is currently investigating the body’s natural response to gliadin in people with CD and gluten sensitivity to identify the very early event(s) responsible for the development of gluten spectrum disorders. Understanding these pathways may offer new preventive and therapeutic strategies for CD and possibly other autoim­mune diseases.
  • Infant Nutrition and Risk of Celiac Disease – We continue to work on this study and have enrolled over 750 babies worldwide to examine whether delaying the introduction of gluten to an infant’s diet may prevent the onset of CD in genetically at-risk infants. If you are interested in this study, please email glutenproject@peds.umaryland.edu.
  • Possible Link Between Schizophrenia and CD/GS – The CFCR continues to investigate this link and the preliminary observa­tions suggest that 1 out of 5 could be affected by gluten sensitivity and, therefore, can potentially benefit from a gluten-free diet.
  • Microbiome and Risk of Gluten-Related Disorders – The Chemotaxis and Autism Speaks Studies are looking at the changes in the normal internal flora and how that may relate to the development of celiac disease, gluten sensitivity and autism.
  • Possible Link Between Autism and CD/GS – The CFCR is investigating a link between autism and gluten sensitivity. This study could potentially help identify the individuals with autism and gluten sensitivity who might benefit from a gluten-free diet.
  • Celiac Disease Research Registry – The CFCR’s celiac disease registry continues to expand, which will enable us to learn more about gluten-related disorders, their complications and co-morbidities.
  • Update on Alba Therapeutics – The CFCR continues to focus some of its research activities to develop alternative/integrated strategies to the gluten-free diet. Our efforts continue to provide the rationale for Alba Therapeutics to perform the clinical trials necessary to exploit these strategies.

Research Studies Currently Recruiting Participants

Infant Nutrition and Risk of Celiac Disease: Proposal for an Intervention, Prospective, Multicenter Study

The Center is working to develop a major intervention study in neonates aimed at establishing whether the timing of gluten introduction in the diet of infants, genetically at risk for celiac disease, may affect the chance to develop the disease. To enroll in this study, or for more information, please email glutenproject@peds.umaryland.edu.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: